Dependency of Ion Permeation Pattern on K+ Concentration through the Kv1.2 Channel
نویسندگان
چکیده
منابع مشابه
Ion permeation through neuronal nAChR ion channel
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متن کاملModeling the concentration-dependent permeation modes of the KcsA potassium ion channel.
The potassium channel from Streptomyces lividans (KcsA) is an integral membrane protein with sequence similarity to all known potassium channels, particularly in the selectivity filter region. A recently proposed model for ion channels containing either n or (n-1) single-file ions in their selectivity filters [P. H. Nelson, J. Chem. Phys. 177, 11396 (2002)] is applied to published KcsA channel ...
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چکیده ندارد.
15 صفحه اولA microscopic view of ion conduction through the K+ channel.
Recent results from x-ray crystallography and molecular dynamics free-energy simulations have revealed the existence of a number of specific cation-binding sites disposed along the narrow pore of the K+ channel from Streptomyces lividans (KcsA), suggesting that K+ ions might literally "hop" in single file from one binding site to the next as permeation proceeds. In support of this view, it was ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.711